Our lab performs research in the field of 3D chromosomal architecture underlying physiological and pathological mechanisms in cancer and immunology. Chromosomal architecture is an emerging feature of epigenetic regulation by which the relative position of genomic elements in the nucleus of the cells affects gene expression and phenotype. Our lab has devoted considerable effort to understanding the changes in 3D chromosomal architecture that occur during the acquisition of humoral immunity and B-cell terminal differentiation. Our studies are mainly done in the context of normal B cells and lymphoma, and other cancer types. Our research uses cell lines, organoid systems, in vivo mouse models, and patient samples. We are also interested in developing new research techniques and tools to better model the different stages of B cell development and acquisition of malignant traits.